Health Human Disease Blog

As in Bartter’s syndrome, hypokalemia, hyper-kaliuria, and hypochloremic metabolic alkalosis characterize this rare disorder. However, in sharp contrast to Bartter’s syndrome, aldosterone levels are normal, renal avidity for sodium is increased, and patients are hypertensive in Liddle’s syn­drome. A primary increase in distal nephron so­dium absorption, which can be blocked by the di­uretic triamterene but not by the aldosterone antagonist spironolactone, appears to be the cause of the unusual clinical syndrome.